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Hvis en pasient har brukt større doser sovemidler above lengre tid, kan han få sterke plager når han prøver å trappe ned: Allergisk hævelse i ansigtet samt mundhulen og strubehovedet, Anafylaktisk chok - en akut alvorlig allergisk tilstand. Midlet bør desuden ikke anvendes ved meget dårligt fungerende lunger og alvorlig søvnapnø (korte